eLife15h
Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...
eLife19h
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies. Non-small cell lung cancer (NSCLC) is the most common subtype of lung ...
eLife19h
HIV integrase compacts viral DNA into biphasic condensates
Soft Condensed Matter and Biophysics, Department of Physics and Debye Institute, Utrecht University, Utrecht, The Netherlands ...
eLife20h
Reconstructing the evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene
Series of paleomaps visualising the geographical and chronological aspects of the main events during the evolutionary history of the freshwater fish family Nemacheilidae across Eurasia. A red star ...
eLife21h
Discovering Root Causal Genes with High Throughput Perturbations
We now introduce an algorithm called Root Causal Strength using Perturbations (RCSP) that discovers the surrogate ancestors of each variable using Perturb-seq and then computes the RCS of each ...
eLife1d
Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, ...
eLife1d
Arthropods dominate plant litter decomposition in drylands
An analysis of leaf litter breakdown in climatically diverse habitats shows that decomposition by larger invertebrates ...
eLife1d
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...
eLife1d
Maternal behavior influences vocal practice and learning processes in the greater sac-winged bat
Smithsonian Tropical Research Institute, Luis Clement Avenue, Bldg. 401 Tupper, Balboa Ancon, Republic of Panama ...
eLife2d
The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2
The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex joined to a displaced strand of genomic DNA. While the effects of R-loops on health and disease are well ...
eLife1d
Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking
These are valuable findings for those interested in how neural signals reflect auditory speech streams, and in understanding the roles of prediction, attention, and eye movements in this tracking.
eLife1d
A novel method (RIM-Deep) enhances imaging depth and resolution stability of deep-cleared brain tissue in inverted confocal microscopy
The increasing use of tissue clearing techniques underscores the urgent need for cost-effective and simplified deep imaging methods. While traditional inverted confocal ...