eLife2h
Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking
These are valuable findings for those interested in how neural signals reflect auditory speech streams, and in understanding the roles of prediction, attention, and eye movements in this tracking.
eLife2h
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth ...
eLife2h
C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice
This important study provides solid in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays ...
eLife3h
A novel method (RIM-Deep) enhances imaging depth and resolution stability of deep-cleared brain tissue in inverted confocal microscopy
The increasing use of tissue clearing techniques underscores the urgent need for cost-effective and simplified deep imaging methods. While traditional inverted confocal ...
eLife4d
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome
This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...
eLife5d
Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish
Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.
eLife3d
Ribosome demand links transcriptional bursts to protein expression noise
This interesting study focuses on a previously reported positive correlation between translational efficiency and protein noise. This is unexpected as typically noise is inversely related to ...
eLife3d
Heat Shock Factor Regulation of Antimicrobial Peptides Expression Suggests a Conserved Defense Mechanism Induced by Febrile Temperature in Arthropods
China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Guangzhou, China ...
eLife6d
IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders
This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the ...
eLife3d
Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos
This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...
eLife6d
PD-1 negatively regulates helper T cell differentiation into Th2
This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...
eLife7d
Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development
This is an important piece of work that sheds light on our understanding of early lung development. There is solid evidence that there is a key new role for Svep1, which may be acting via FGF9. A more ...